Professor Dale Bredesen
Hope for cognitive decline and prevention of Alzheimer's
Professor Bredesen says we need to measure our brain-health biomarkers in the same way we do cholesterol and blood pressure. His RECODE lifestyle programme to reverse memory decline has revolutionised treatment for dementia, a disease he describes as an ’emergency’. Dr Hart is an accredited RECODE practitioner.
Follow this link to read more about Dr Dale Bredesen
Follow this link to read more about the science behind the protocol
Professor Bredesen and his team have identified multiple subtypes of Alzheimer’s disease using extensive 21-st century metabolic profiling (Bredesen, Aging 2015), identifying new and previously unrecognized causes of Alzheimer’s disease (Aging 2016), and developed a continuously evolving version of Dr. Bredesen’s original MEND program.
Alzheimer's Disease (AD) has been categorised into 4 types of causes by Dr Dale Bredesen at the Buck Institute for Research into Aging. Any person can have any combination of these causes.
Type 1 - inflammatory - inflammation is triggered in the brain, leading to the withdrawal of connections between neurons, and then neuronal cell death. There are many possible triggers of neuro-inflammation, including high blood sugar and advanced glycation end-products, chronic infections and increased intestinal permeability (leaky gut). Identifying the triggers of inflammation, and removing them, can lead to the growth of new connections between neurons, and the growth of new neurons, especially in the memory centre of the brain (hippocampus).
Type 2 - atrophic - the loss of hormones and nutrients that cause neuron growth and support their function. These hormones include growth hormone, IGF-1, testosterone, estradiol, progesterone, tri-iodothyronine (T3), calcitriol (vitamin D). Nutrients include magnesium, zinc, calcium, potassium, and vitamins A, B2, B6, B9, B12, C, E. Identifying missing hormones and nutrients, and replacing them, can trigger the growth of new connections between neurons, and the growth of new neurons. This results in increased cognitive function and memory, and the ability to better perform the activities of daily living.
Type 1.5 - glycotoxic. This type is a combination of Types 1 and 2. It is due to the inflammatory effect of high blood sugar (glycation of proteins by glucose causing advanced glycation end products) combined with the neurotrophic withdrawal of insulin's growth support by insulin resistance (high insulin levels in the blood, but not working in the cells).
Type 3 - toxic. This type is caused by infections and toxins that trigger neuroinflammation and nerve cell dysfunction and death. Infections include viral (HSV, EBV, CMV, HSV6), bacterial (Borrelia, Babesia, Bartonella, P. gingivalis, T. denticola, nasal MARCoNS), fungi and parasites. Toxins include mercury (from dental amalgams and fish), aluminium (and other heavy metals and minerals), mycotoxins (from fungi in the environment or growing on (intranasal, intrasinus) or in the body (in the biofilm on foreign objects - dental implants, joint implants, breast implants). Common mycotoxins are trichothenes (Stachybotrys), Ochratoxin A (Penicillium), and aflatoxin (Aspergillus). Removing the source of the infection or toxicity and repairing the damage done allows nerve cells to regrow, and cognitive function to improve.
Identifying which factors apply to an individual with cognitive decline, and reversing them, leads to improvement in cognitive function, and the reversal of subjective cognitive impairment (SCI), mild cognitive impairment (MCI), and if caught early enough, even Alzheimer's Disease.